The CDK5R1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CDK5R1. This antibody recognizes Human, Mouse, and Rat antigen. The CDK5R1 Antibody has been validated for the following applications: Immunofluorescence, and Western Blot.
Description
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.Tsai L.-H., Nature 371:419-423(1994).Patrick G.N., Nature 402:615-622(1999).Kesavapany S., J. Neurosci. 24:4421-4431(2004)